Synthesis and Characterization of Chitosan-Acrylic Acid Based Hydrogels and Investigation the Properties of Bilayered Design with Incorporated Alginate Beads

The paper presents the synthesis of hydrogels via free-radical polymerization, based on Chitosan (CS) grafted with Acrylic acid (AA), using a two-step procedure. Free-radical polymerization has given strong compact structure, dominant elastic behavior, and long linear viscoelastic region. results rheological studies have shown that obtained significantly improved mechanical properties in comparison to chitosan by other sustainable methods. A step forward investigation potential application wound dressing systems been made preparation bilayer design embedding layer active compound-loaded alginate beads into contact surface between two conjoined units CS/AA hydrogels. Wild garlic (Allium ursinum L.) dried extract was used as an compound because its antimicrobial activity green properties. This system demonstrated pH-dependent release higher shear modulus values than ordinary disc gels. conducted study preliminary for possible chitosan-based represents first towards extrapolating proposed across fields.